Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)
Ester Álvarez‐Benedicto, Lukas Farbiak, Martha Márquez Ramírez, Xu Wang, Lindsay T. Johnson, Osamah Mian, Erick Guerrero, Daniel J. Siegwart
Abstract
. These findings were then applied to Selective Organ Targeting (SORT) LNPs to manipulate and control spleen-specific delivery. Overall, selection of the phospholipid in LNPs provides an important handle to design and optimize LNPs for improved mRNA delivery and more effective therapeutics.
Topics & Concepts
EndosomePhospholipidMessenger RNAChemistryNucleic acidCell biologyRNALiposomeIn vivoBiochemistryBiologyMembraneGeneCellGeneticsRNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 ResearchLipid Membrane Structure and Behavior