ROS-scavenging nanomedicine for “multiple crosstalk” modulation in non-alcoholic fatty liver disease
Xiaofei Xin, Jingjing Li, Wantao Wu, Pengbo Zhao, Yang Yang, Ying Zhu, Lianjie Ren, Chao Qin, Lifang Yin
Abstract
-induced mice, RLL intervention remarkably improved metabolic profiles and reduced the fibrosis lesions. Our results provided a strategy for the amelioration of oxidative stress and CYP450 activity using ROS-responsive thioketal as an antioxidant adjuvant facilitated by nanotechnology.
Topics & Concepts
NanomedicineCrosstalkAlcoholic liver diseaseFatty liverChemistryModulation (music)Cell biologyNanotechnologyBiochemistryDiseaseBiologyNanoparticleMedicinePhysicsMaterials scienceInternal medicineCirrhosisAcousticsOpticsLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsHepatitis C virus research