Potent antiproliferative active agents: novel bis Schiff bases and bis spiro β-lactams bearing isatin tethered with butylene and phenylene as spacer and DNA/BSA binding behavior as well as studying molecular docking
Mohammad Bashiri, Aliasghar Jarrahpour, S. Masoud Nabavizadeh, Somaye Karimian, Banafsheh Rastegari, Elahe Haddadi, Edward Turos
Topics & Concepts
IsatinChemistryHeLaDocking (animal)MTT assaySchiff baseCytotoxicityProton NMRStereochemistryCisplatinCombinatorial chemistryIn vitroBiochemistryOrganic chemistryNursingChemotherapySurgeryMedicineSynthesis of β-Lactam CompoundsMetal complexes synthesis and propertiesSynthesis and Biological Evaluation