LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22
Ke‐Wei Zhu, Yuan Yang, Jie Wen, Chen Ding, Weihong Zhu, Zhengxiao Ouyang, Wanchun Wang
Abstract
, while miR-22 inhibition or miR-142 inhibition reverses the effects of Sox2OT-V7 silencing on Dox-induced suppression on tumor growth. Finally, miR-142 directly targets ULK1, ATG4A, and ATG5, while miR-22 directly targets ULK1 to inhibit the expression of the target gene; The Sox2OT-V7/miR-142/miR-22 axis modulates autophagy in OS cells by regulating ULK1, ATG4A, and ATG5.
Topics & Concepts
OsteosarcomaDoxorubicinAutophagyCancer researchMedicineChemotherapyChemistryInternal medicineApoptosisBiochemistryCancer-related molecular mechanisms researchAutophagy in Disease and TherapyRNA modifications and cancer