HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway
Yajin Liao, Jinbo Cheng, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Meijuan Zhang, He Zhang, Tianli Yang, Yuan Dong, Jun Li, Yun Xu, Zengqiang Yuan
Abstract
Collectively, we elucidated that the HDAC3-p65-cGAS-STING pathway is involved in the development of I/R-induced neuroinflammation, identifying a new therapeutic avenue for the treatment of ischemic stroke.
Topics & Concepts
NeuroinflammationMicrogliaCell biologyChemistryReperfusion injuryBiologyCancer researchPharmacologyImmunologyIschemiaInflammationMedicineInternal medicineinterferon and immune responsesInflammasome and immune disordersImmune Response and Inflammation