Terminal-Selective C(sp<sup>3</sup>)–H Arylation: NiH-Catalyzed Remote Hydroarylation of Unactivated Internal Olefins
Yuli He, Bo Han, Shaolin Zhu
Abstract
A terminal-selective migratory hydroarylation of unactivated olefins has been developed though a NiH-catalyzed alkene isomerization–hydroarylation relay process. This sp3 C–H arylation was achieved with a simple pyrox ligand under mild conditions. The practicality and synthetic flexibility of the method is highlighted by the successful regioconvergent conversion of isomeric mixtures of alkenes to value-added linear arylation products on a gram scale.
Topics & Concepts
ChemistryIsomerizationCatalysisAlkeneLigand (biochemistry)Combinatorial chemistryTerminal (telecommunication)Medicinal chemistryOrganic chemistryReceptorBiochemistryComputer scienceTelecommunicationsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions