Asymmetric Hydrophosphinylation of Alkynes: Facile Access to Axially Chiral Styrene‐Phosphines
Baohua Cai, Yuan Cui, Jian Zhou, Yong‐Bin Wang, Limin Yang, Bin Tan, Jun Wang
Abstract
A Cu/CPA co-catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus-containing alkenes in high yields and excellent enantioselectivities (up to 99 % yield and 99 % ee). DFT calculations were performed to elucidate the reaction pathway and the origin of enantiocontrol. This streamlined and modular methodology establishes a new platform for the design and application of new axially chiral styrene-phosphine ligands.
Topics & Concepts
StyreneAxial symmetryChemistryCombinatorial chemistryOrganic chemistryPhysicsCopolymerPolymerQuantum mechanicsAxial and Atropisomeric Chirality SynthesisAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis