Maternal supplementation with<i>Artemisia annua</i>L. ameliorates intestinal inflammation<i>via</i>inhibiting the TLR4/NF-κB and MAPK pathways and improves the oxidative stability of offspring
Shihai Zhang, Liang Xiong, Chang Cui, Hao Zhao, Yufeng Zhang, Zhezhe Tian, Wutai Guan, Fang Chen
Abstract
< 0.05). Together, these results showed that maternal 0.1% AAE supplementation improved the redox status and attenuated the neonatal and early-weaning associated inflammatory response in the offspring's small intestine, possibly by suppressing the activation of the TLR4/NF-κB and MAPK inflammatory pathways, and stimulated expressions of beta-defensins, mucins, and PPARγ to promote inflammation resolution and innate immunity response.
Topics & Concepts
TLR4MAPK/ERK pathwayInflammationOffspringOxidative stressNF-κBArtemisia annuaSignal transductionChemistryImmunologyPharmacologyMedicineBiologyCell biologyArtemisininInternal medicinePregnancyMalariaPlasmodium falciparumGeneticsImmune Response and InflammationFatty Acid Research and HealthReproductive System and Pregnancy