Synthesis of porphyrin-incorporating covalent organic frameworks for sonodynamic therapy
Sainan Liu, Ying Zhou, Chunling Hu, Lihan Cai, Zhendong Liu, Maolin Pang
Abstract
Porphyrin-incorporating covalent organic frameworks were synthesized at room temperature. The resulting products with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated the significant antitumor efficiency via sonodynamic therapy.
Topics & Concepts
Sonodynamic therapyPorphyrinCovalent bondChemistryPhotodynamic therapyCombinatorial chemistryMaterials sciencePhotochemistryOrganic chemistryCovalent Organic Framework ApplicationsNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials