Older age and male sex are associated with higher cerebrovascular impedance
Jun Sugawara, Takashi Tarumi, Changyang Xing, Jie Liu, Tsubasa Tomoto, Evan Pasha, Rong Zhang
Abstract
Impedance modulus at the first harmonics of cerebral blood flow velocity (CBFV) and carotid artery pressure oscillations (Z 1 ) was higher in the old (>64 yr) than in the young individuals (<45 yr), and it was higher in men than in women. Z 1 is negatively associated with CBFV after adjustment for age, sex, and body mass index. Increases in cerebrovascular impedance with age may buffer systemic arterial pressure fluctuations at the cost of increased brain hypoperfusion risk.
Topics & Concepts
Pulsatile flowCardiologyMedicineCerebral blood flowInternal medicineBlood pressureCerebral perfusion pressureMiddle cerebral arteryTranscranial DopplerCerebral autoregulationIschemiaAutoregulationCardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesOptical Imaging and Spectroscopy Techniques