Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
Shaquib Rahman Ansari, Nele‐Johanna Hempel, Shno Asad, Peter Svedlindh, Christel A. S. Bergström, Korbinian Löbmann, Alexandra Teleki
Abstract
and 30 wt % celecoxib in the tablets that reached the maximum temperature of 165.2 °C after 15 min of AMF exposure. Furthermore, manganese ferrite exhibits no toxicity in human intestinal Caco-2 cell lines. The resulting maximum solubility of in situ amorphized celecoxib is 5 times higher than that of crystalline celecoxib in biorelevant intestinal fluid. This demonstrates the promising capability of SPIONs as enabling excipients to magnetically induce amorphization in situ in oral dosage forms.
Topics & Concepts
Materials sciencePolyvinylpyrrolidoneDrugNanoparticleAqueous solutionHyperthermiaChemical engineeringSolubilityDosage formAmorphous solidMagnetic hyperthermiaDrug deliveryNanotechnologyPharmacologyChromatographyOrganic chemistryMagnetic nanoparticlesChemistryPolymer chemistryMedicineInternal medicineEngineeringNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems