Synthesis of novel naphthalene-heterocycle hybrids with potent antitumor, anti-inflammatory and antituberculosis activities
Mohamed Ahmed Abozeid, Aya Atef El‐Sawi, Mohamed Abdelmoteleb, Hanem M. Awad, Marwa M. Abdel‐Aziz, Abdel-Rahman Hassan Abdel-Rahman, El‐Sayed I. El‐Desoky
Abstract
Novel naphthalene-heterocycle hybrids were synthesized <italic>via</italic> tandem reactions of 3-formylchromone with different nucleophilic reagents. Various hybrids revealed potent antitumor and anti-inflammatory as well as promising antituberculosis activities.
Topics & Concepts
ChemistryCombinatorial chemistryDocking (animal)NaphthaleneAnti-inflammatoryCelecoxibHybridDoxorubicinPyrazoleIndole testStereochemistryPharmacologyBiochemistryOrganic chemistryBiologyMedicineChemotherapyNursingBotanyGeneticsSynthesis and biological activitySynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles