Experimental Estimation of 44 Pharmaceutical Polar Organic Chemical Integrative Sampler Sampling Rates in an Artificial River under Various Flow Conditions
Robin Guibal, Sophie Lissalde, Gilles Guibaud
Abstract
Abstract The present study pertains to a polar organic chemical integrative sampler (POCIS) laboratory calibration to estimate the sampling rates for 44 pharmaceuticals featuring a wide range of polarity (–0.6 < octanol/water partition coefficient [log KOW] < 5.4). The calibration was performed at 16.0 ± 1.5 °C for 4 water flow velocities (0, 2–3, 6–7, and 20 cm/s) in both a tank (for calibration at 0 cm/s) and a laboratory-scale artificial river filled with 200 and 500 L of tap water spiked with 0.3 µg/L of each compound, respectively. Twelve new sampling rates and 26 sampling rates already available in the literature were determined, whereas the sampling rates for 6 pharmaceuticals could not be determined due to nonlinearity or poor accumulation in POCIS. An increase in the sampling rate value with flow velocity was observed, which is consistent with a decrease in the effective thickness of the water boundary layer at the POCIS membrane surface. Environ Toxicol Chem 2020;39:1186–1195. © 2020 SETAC