Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients
Lakshin Kumar, Sayan Dasgupta, Cristina Murray‐Krezan, Nina Singh, Robert M. Rakita, Cynthia E. Fisher, Ajit P. Limaye
Abstract
In a post-hoc analysis of the association of CMV DNAemia with long-term mortality in a randomized trial of CMV preemptive therapy vs. antiviral prophylaxis in D+R- liver transplant recipients, post-intervention CMV DNAemia was associated with increased mortality after adjusting for study arm.
Topics & Concepts
MedicineCytomegalovirusRandomized controlled trialPost-hoc analysisAntiviral therapyInternal medicineHuman cytomegalovirusBetaherpesvirinaeLiver transplantationImmunologyViral diseaseTransplantationHerpesviridaeVirusChronic hepatitisCytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsViral-associated cancers and disorders