The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Victoria H. Wu, Bryan S. Yung, Farhoud Faraji, Robert Saddawi‐Konefka, Zhiyong Wang, Alexander T. Wenzel, Miranda Song, Meghana S. Pagadala, Lauren Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas S. Hoang, Rebecca Berdeaux, Dario A.A. Vignali, Ramiro Iglesias‐Bartolomé, Hannah Carter, Eytan Ruppin, Jill P. Mesirov, J. Silvio Gutkind
Topics & Concepts
DruggabilityCD8ImmunotherapyG protein-coupled receptorImmune systemT cellImmune checkpointCancer immunotherapyCancer researchCytotoxic T cellBiologyEffectorSignal transductionCell biologyImmunologyBiochemistryIn vitroGeneReceptor Mechanisms and SignalingCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction