Tuning the photoactivated anticancer activity of Pt(<scp>iv</scp>) compounds <i>via</i> distant ferrocene conjugation
Huayun Shi, Fortuna Ponte, Jaspreet Singh Grewal, Guy J. Clarkson, Cinzia Imberti, Ian Hands-Portman, Robert Dallmann, Emilia Sicilia, Peter J. Sadler
Abstract
fragment. Visible light irradiation gives rise to micromolar activity for Pt-Fe towards ovarian, lung, prostate and bladder cancer cells under both normoxia and hypoxia, and some photoproducts appear to retain Pt(iv)-Fe(ii) conjugation.
Topics & Concepts
FerroceneChemistryCombinatorial chemistryStereochemistryElectrochemistryElectrodePhysical chemistryFerrocene Chemistry and ApplicationsMolecular Junctions and NanostructuresAdvanced biosensing and bioanalysis techniques