DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9
Yajing Shi, Min Duan, Junmei Ding, Fan-Qi Wang, Lili Bi, Caixiang Zhang, Yizhou Zhang, Yi-Zhou Zhang, Junyi Duan, An-Hui Huang, Xinlin Lei, Hao Yin, Ying Zhang, Ying Zhang
Topics & Concepts
Cas9BiologyDNAGenome editingCRISPRPlasmidCleaveDNA supercoilProtein–DNA interactionCell biologyTopology (electrical circuits)GeneticsMolecular biologyDNA-binding proteinGeneDNA replicationTranscription factorMathematicsCombinatoricsCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques