A Recombinant Dimethylarginine Dimethylaminohydrolase-1–Based Biotherapeutics to Pharmacologically Lower Asymmetric Dimethyl Arginine, thus Improving Postischemic Cardiac Function and Cardiomyocyte Mitochondrial Activity
Young Lee, Jaipal Singh, Susan R. Scott, Bradley Ellis, Pinar Zorlutuna, Meijing Wang
Topics & Concepts
Asymmetric dimethylarginineContractilityCardiac function curveCardioprotectionPharmacologyProinflammatory cytokineCytokineMedicineHypoxia (environmental)Nitric oxideInternal medicineMitochondrionArginineHeart failureEndocrinologyInflammationMitochondrial ROSIn vivoMyocyteRecombinant DNAReactive oxygen speciesChemistryEndotheliumBioenergeticsNitric Oxide and Endothelin EffectsCancer-related gene regulationCardiac Fibrosis and Remodeling