Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide
Rufei Huang, Huan Xia, Tao Meng, Yufei Fan, Xun Tang, Yifang Li, Tiantian Zhang, Jingxian Deng, Bing Yao, Yadong Huang, Yang Yan
Abstract
These findings introduced a method for generating testicular organoids from human pluripotent stem cells, highlighting their potential as valuable models for studying testicular function, drug toxicity, and the effects of compounds like semaglutide on testicular health.
Topics & Concepts
OrganoidInduced pluripotent stem cellHumanized mouseStem cellBiologyCancer researchCell biologyImmunologyEmbryonic stem cellBiochemistryImmune systemGeneTesticular diseases and treatmentsRenal and related cancersPluripotent Stem Cells Research