Multivalent butyrylcholinesterase inhibitor discovered by exploiting dynamic combinatorial chemistry
Shuang Zhao, Jintao Xu, Shixin Zhang, Maochun Han, Wu Yao, Yusi Li, Lei Hu
Topics & Concepts
ButyrylcholinesteraseChemistryAcetylcholinesteraseSide chainCombinatorial chemistryIn vitroSelectivityBiochemistryAchéStereochemistryEnzymeOrganic chemistryPolymerCatalysisCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsChemical Synthesis and Analysis