Electrocatalytic Cascade Selenylation/Cyclization/Deamination of 2-Hydroxyaryl Enaminones: Synthesis of 3-Selenylated Chromones under Mild Conditions
Kaili Cen, Yuan Liu, Junhong Yu, Zhouting Zeng, Qian Hou, Guojun He, Mixia Ouyang, Qiaolin Wang, Dahan Wang, Feng Zhao, Jinhui Cai
Abstract
Herein, we disclosed a highly efficient pathway toward 3-selenylated chromone derivatives via electrocatalytic cascade selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amendable to scale-up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.
Topics & Concepts
ChemistryChromoneDeaminationElectrosynthesisCascade reactionCombinatorial chemistryCascadeSubstrate (aquarium)Organic chemistryCatalysisElectrochemistryEnzymeElectrodeChromatographyPhysical chemistryOceanographyGeologySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods