Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells
Garry L. Coles, Sandra Cristea, James T. Webber, Rebecca S. Levin, Steven M. Moss, Andy He, Jaya Sangodkar, Yeonjoo Hwang, Julia Arand, Alexandros P. Drainas, Nancie A. Mooney, János Demeter, Jessica N. Spradlin, Brandon Mauch, Vicky Le, Yan Ting Shue, Julie H. Ko, Myung Chang Lee, Christina S. Kong, Daniel K. Nomura, Michael Ohlmeyer, Danielle L. Swaney, Nevan J. Krogan, Peter K. Jackson, Goutham Narla, John D. Gordan, Kevan M. Shokat, Julien Sage
Topics & Concepts
GNAS complex locusProtein phosphatase 2Activator (genetics)Protein kinase ABiologyCancer researchKinaseCell biologyPhosphoproteomicsProtein subunitPhosphataseSuppressorStem cellPhosphorylationCancerReceptorBiochemistryGeneticsGeneProtein phosphorylationLung Cancer Research StudiesAdvanced biosensing and bioanalysis techniquesPeptidase Inhibition and Analysis