Synthesis and Characterization of an Inclusion Complex of <scp>dl</scp>-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations
Samapika Ray, Niloy Roy, Biraj Kumar Barman, Paramita Karmakar, Pranish Bomzan, Biplab Rajbanshi, Vikas Kumar Dakua, Ankita Dutta, Anoop Kumar, Mahendra Nath Roy
Abstract
Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a β-CD molecule. The consequential inclusion system was characterized by UV–visible spectroscopy and 1H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the inclusion complex to discover the most proper orientation, and it was seen that the drug DL-AGT fits into the cavity of β-CD in a 1:1 ratio, which was also confirmed from the Job plot. Furthermore, a comparison was done on the basis of cell viability between the drug and its inclusion complex.
Topics & Concepts
CyclodextrinDocking (animal)MoleculeChemistryInclusion (mineral)CrystallographyPowder diffractionStereochemistryCombinatorial chemistryMaterials scienceOrganic chemistryMineralogyMedicineNursingDrug Solubulity and Delivery SystemsAnalytical Chemistry and ChromatographyProtein Interaction Studies and Fluorescence Analysis