Sulfation Code and Conformational Plasticity of <scp>l</scp>-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate
Chethan D. Shanthamurthy, Ana Gimeno, Shani Leviatan Ben‐Arye, Nanjundaswamy Vijendra Kumar, Prashant Ankur Jain, Vered Padler‐Karavani, Jesús Jiménez‐Barbero, Raghavendra Kikkeri
Abstract
), which in a multivalent display modulated endothelial cell proliferation, migration, and angiogenesis. Overall, these results encourage the consideration of HS mimics for therapeutic applications.
Topics & Concepts
SulfationIduronic acidChemistryHeparan sulfateBiochemistryOligosaccharideAngiogenesisSulfotransferaseStereochemistryGlycosaminoglycanBiologyCancer researchProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis