A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
Melissa Ruggiero, Shipra Malhotra, Aron W. Fenton, Liskin Swint‐Kruse, John Karanicolas, Bruno Hagenbuch
Abstract
/TCA cotransporting polypeptide structure model. Across the modest range of changes, calculated stabilities correlated with surface-expression differences, but neither parameter correlated with altered transport. Thus, substitutions at rheostat position 267 had wide-ranging effects on the phenotype of this integral membrane protein. We further propose that polymorphic positions in other proteins might be locations of rheostat positions.
Topics & Concepts
Amino acidProtein structureBiologyBiophysicsChemistryBiochemistryDrug Transport and Resistance MechanismsDiabetes Treatment and ManagementPharmacological Effects and Toxicity Studies