Copper-catalysed chemoselective C–OH bond activation of <i>N</i>-benzoyl cytosine: facile access to 2-(dimethylamino)pyrimidine
Sujeet Gaware, Rana Chatterjee, Anant R. Kapdi, Rambabu Dandela
Abstract
) sources. Moreover, the facile nature of the procedure, its broad tolerance of aliphatic and aromatic substrates, the high yields and ease of separation of the products, and the fact that it can be conducted under aerobic conditions are all notable advantages of the present protocol.
Topics & Concepts
ChemistryAminationPyrimidineFormamideCatalysisDimethyl formamideCombinatorial chemistryDimethylformamideCopperOrganic chemistryMedicinal chemistryStereochemistrySolventCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions