Modeling the effect of vaccination on selection for antibiotic resistance in <i>Streptococcus pneumonia</i> <i>e</i>
Nicholas G. Davies, Stefan Flasche, Mark Jit, Katherine E. Atkins
Abstract
antibiotic resistance. We found that the relative strength and directionality of competition between drug-resistant and drug-sensitive pneumococcal strains was the most important determinant of whether vaccination would promote, inhibit, or have little effect upon the evolution of antibiotic resistance. Last, we show that country-specific differences in pathogen transmission substantially altered the predicted impact of vaccination, highlighting that policies for managing antibiotic resistance with vaccines must be tailored to a specific pathogen and setting.
Topics & Concepts
Streptococcus pneumoniaeAntibiotic resistanceAntibioticsVaccinationPenicillinMicrobiologyBiologyPathogenPneumococcal infectionsCarriageAntibiotic sensitivityPneumoniaDrug resistanceImmunologyVirologyMedicineInternal medicinePathologyPneumonia and Respiratory InfectionsBacterial Infections and VaccinesAntibiotic Use and Resistance