B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates
Md. Alamgir Hossain, Kara Anasti, Brian Watts, Kenneth Cronin, Ronald Derking, Bettina Gröschel, Advaiti Pai Kane, R. J. Edwards, David Easterhoff, Jinsong Zhang, Wes Rountree, Yaneth Ortiz, Kevin O. Saunders, William R. Schief, Rogier W. Sanders, Laurent Verkoczy, Michael Reth, S. Munir Alam
Abstract
but on sensing of association rate and a threshold antigen-BCR half-life.
Topics & Concepts
AntigenAntibodyInternalizationB-cell receptorAffinitiesReceptorMolecular biologyB cellBiologyEpitopeChemistryVirologyImmunologyBiochemistryT-cell and B-cell ImmunologyImmune Cell Function and InteractionHIV Research and Treatment