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Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities

Xiaoyu Zhang, Wei Wang, Guoqiang Dong, Yingqi Song, Xin Zhai, Chunquan Sheng

2024Bioorganic & Medicinal Chemistry Letters12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryProteasomeDrug discoveryProteolysisWestern blotUbiquitinPotencyCancer researchPharmacologyBiochemistryEnzymeIn vitroBiologyGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways
Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities | Litcius