Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program
Javier Arranz‐Nicolás, Miguel Martin-Salgado, Irene Adán‐Barrientos, Rosa Liébana, María del Carmen Moreno-Ortíz, Judith Leitner, Peter Steinberger, Antonia Ávila‐Flores, Isabel Mérida
Topics & Concepts
Diacylglycerol kinaseCancer researchT cellCytotoxic T cellDownregulation and upregulationCD8BiologyAntigenCell biologyKinaseImmune systemImmunologyProtein kinase CIn vitroBiochemistryGeneCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionT-cell and B-cell Immunology