Identification of xanthine oxidase inhibitors through hierarchical virtual screening
Ying Yang, Lei Zhang, Jin‐Ying Tian, Fei Ye, Zhiyan Xiao
Abstract
A new chemotype of XO inhibitor with the IC<sub>50</sub> of 2.6 μM was identified by a hierarchical virtual screening strategy.
Topics & Concepts
Virtual screeningXanthine oxidaseChemistryDocking (animal)Computational biologyXanthine oxidase inhibitorEnzymeBiochemistryXanthineIC50Combinatorial chemistryPharmacologyDrug discoveryBiologyMedicineIn vitroNursingGout, Hyperuricemia, Uric AcidHepatitis C virus researchCase Reports on Hematomas