Asymmetric rhodium-catalyzed click cycloaddition to access C–N axially chiral<i>N</i>-triazolyl indoles
Li Zhou, Yankun Li, Shunian Li, Zhenwei Shi, Xue Zhang, Chen‐Ho Tung, Zhenghu Xu
Abstract
-alkynylindoles with azides was developed, providing atroposelective access to C-N axially chiral triazolyl indoles, a new type of heterobiaryl, with excellent yields and enantioselectivity. This asymmetric approach is efficient, mild, robust and atom-economic, and features very broad substrate scope with easily available Tol-BINAP ligands.
Topics & Concepts
CycloadditionClick chemistryTriazoleChemistryCatalysisCombinatorial chemistryRhodiumAzideAlkyneEnantioselective synthesisSubstrate (aquarium)Medicinal chemistryOrganic chemistryOceanographyGeologyAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions