Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma
Chen Xue, Junjun Jia, Xinyu Gu, Lin Zhou, Juan Lu, Qiuxian Zheng, Yuanshuai Su, Shusen Zheng, Lanjuan Li
Abstract
Hepatocellular carcinoma (HCC), which ranks globally as the third leading cause of cancer-related deaths, is highly prevalent, and most patients are diagnosed with advanced-stage cancer when treatments are largely ineffective. 1 Thus, there is an urgent need for earlier diagnosis to improve HCC patient outcomes.
Topics & Concepts
Hepatocellular carcinomaBacteriaBiologyCancer researchComputational biologyMicrobiologyGeneticsCancer Research and TreatmentsFerroptosis and cancer prognosisCancer Genomics and Diagnostics