Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis
Wangrui Jin, Tao Zhang, Wenbo Zhou, Peng He, Yue Sun, Shijia Hu, Huang Chen, Xinglong Ma, Yangrui Peng, Zhengfang Yi, Mingyao Liu, Yihua Chen
Abstract
. These findings demonstrate that targeting STAT3 may be a feasible therapeutic strategy for the treatment of metastatic osteosarcoma.
Topics & Concepts
OsteosarcomaCancer researchMetastasisSTAT3In vivoApoptosisCell growthChemistryIn vitroInternal medicineMedicineCancerBiologyBiochemistryBiotechnologyCytokine Signaling Pathways and InteractionsQuinazolinone synthesis and applicationsSynthesis and biological activity