Optimization of HPLC CAD method for simultaneous analysis of different lipids in lipid nanoparticles with analytical QbD
Ki‐Hyun Kim, Ji Eun Lee, Jae‐Chul Lee, Ravi Maharjan, Suhyun Oh, Kyeong Lee, Nam Ah Kim, Seong Hoon Jeong, Seong Hoon Jeong
Topics & Concepts
Quality by DesignChemistryChromatographyRobustness (evolution)Box–Behnken designDesign of experimentsLinearityMonte Carlo methodResponse surface methodologySolid lipid nanoparticleDrug deliveryParticle sizeMathematicsStatisticsOrganic chemistryGenePhysicsPhysical chemistryBiochemistryQuantum mechanicsAnalytical Chemistry and ChromatographyAnalytical Methods in PharmaceuticalsAntibiotics Pharmacokinetics and Efficacy