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The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes

Min Lv, Yuanzhen Cai, Weikun Hou, Kan Peng, Ke Xu, Chao Lu, Wenxing Yu, Weisong Zhang, Lin Liu

2022Inflammation Research71 citationsDOI

Topics & Concepts

Gene knockdownChemistryGPX4Cell biologyHeat shock proteinViability assayDownregulation and upregulationCellApoptosisGlutathioneBiochemistryBiologyEnzymeGeneGlutathione peroxidaseFerroptosis and cancer prognosisCancer-related molecular mechanisms researchOsteoarthritis Treatment and Mechanisms
The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes | Litcius