Hippocampal Proteomic Analysis in Male Mice Following Aggressive Behavior Induced by Long-Term Administration of Perampanel
Wu Yang, Lin Ma, Dong-Mei Hai, Ning Liu, Jia-Mei Yang, Xiaobing Lan, Juan Du, Lishan Yang, Tao Sun, Jian Yu
Abstract
) and postsynaptic density 95 (PSD95) were down-regulated in perampanel-treated mice. Therefore, our results provide valuable insight into the molecular mechanisms of aggressive behavior induced by perampanel, as well as potential options for safety treatment of perampanel in the future.
Topics & Concepts
PerampanelHippocampal formationNeuroscienceHippocampusTerm (time)PsychologyMedicineEpilepsyPhysicsQuantum mechanicsNeuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeuropeptides and Animal Physiology