A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4
Yuanyuan Yong, Yan Lu, Jing Wei, Feng Chi, Lu Yu, Jianming Wu, Minsong Guo, Dongsheng Fan, Chong‐Lin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu
Abstract
ThA ameliorates AD by inhibiting neuronal ferroptosis mediated by GPX4 activation through its binding with GPX4 and the upregulation of the AMPK/Nrf2/GPX4 pathway.
Topics & Concepts
DiseaseAlzheimer's diseaseMedicineChemistryNeuroscienceBiologyInternal medicineFerroptosis and cancer prognosisRNA Research and SplicingMicroRNA in disease regulation