Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam
Xavier Buol, Camila Caro Garrido, Koen Robeyns, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens
Abstract
In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98–99%) was obtained with a process that can run for multiple cycles.
Topics & Concepts
Mandelic acidCocrystalChemistryResolution (logic)Chiral resolutionProcess (computing)Combinatorial chemistryStereochemistryOrganic chemistryEnantiomerHydrogen bondMoleculeComputer scienceOperating systemArtificial intelligenceCrystallization and Solubility StudiesCrystallography and molecular interactionsAnalytical Chemistry and Chromatography