Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy
Zachary A. Sorrentino, Ethan Hass, N. Vijayaraghavan, Kimberly-Marie M. Gorion, Cara J. Riffe, Jess-Karan S. Dhillon, Benoit I. Giasson
Topics & Concepts
SynucleinopathiesAlpha-synucleinAmyloid (mycology)Genetically modified mouseCell biologyPhosphorylationProtein foldingBiologyChemistryProtein aggregationTransgeneDiseaseBiochemistryParkinson's diseaseMedicineGenePathologyBotanyParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsNeurological diseases and metabolism