An in-depth examination of fatty acid solubility limits in biotherapeutic protein formulations containing polysorbate 20 and polysorbate 80
Nils Glücklich, Mridula Dwivedi, Stefan Carle, Julia Buske, Karsten Mäder, Patrick Garidel
Topics & Concepts
PolysorbateChemistrySolubilityPolyvinyl alcoholChromatographySorbitanOleic acidHydrolysisPulmonary surfactantAqueous solutionExcipientOrganic chemistryFatty acidFatty acid esterBiochemistryProtein purification and stabilityViral Infectious Diseases and Gene Expression in InsectsDrug Solubulity and Delivery Systems