MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology
Rita Sarkis, Olivier Burri, Claire Royer-Chardon, Frédérica Schyrr, Sophie Blum, Mariangela Costanza, Stéphane Cherix, Nathalie Piazzon, Carmen Bárcena, Bettina Bisig, Valentina Nardi, Rossella Sarro, Giovanna Ambrosini, Martin Weigert, Olivier Spertini, Sabine Blum, Bart Deplancke, Arne Seitz, Laurence de Leval, Olaia Naveiras
Abstract
= 0.86, n = 42). Thus, we conclude that these validation experiments establish MarrowQuant 2.0 as a reliable tool for BM cellularity assessment. We expect this workflow will serve as a clinical research tool to explore novel biomarkers related to BM stromal components and may contribute to further validation of future digitalized diagnostic hematopathology workstreams.
Topics & Concepts
HematopathologyMedicineTrephineBone marrowPathologySegmentationH&E stainStromal cellHematologyMyeloidInternal medicineStainingComputer scienceArtificial intelligenceGeneChromosomeChemistryBiochemistryCytogeneticsHematological disorders and diagnosticsBone and Joint DiseasesHematopoietic Stem Cell Transplantation