Flash Chemistry Makes Impossible Organolithium Chemistry Possible
Aiichiro Nagaki, Yosuke Ashikari, Masahiro Takumi, Takashi Tamaki
Abstract
Organolithium reagents are often too unstable to use due to being highly reactive. This limits their application in organic synthesis. This review highlights our approach to various synthetic reactions mediated by organolithium reagents based on flash chemistry conducted in flow reactors, especially utilizing space-integration of the flow reactions. The high reactivity of organolithiums often renders them too unstable to use, thereby limiting their application in organic synthesis. This review highlights our approaches for synthetic reactions mediated by organolithiums based on Flash chemistry in flow reactors, especially utilizing space-integration of flow reactions.
Topics & Concepts
ChemistryFlash (photography)Flow chemistryLimitingReagentReactivity (psychology)Organic synthesisCombinatorial chemistryOrganic chemistryBiochemical engineeringCatalysisEngineeringMedicineMechanical engineeringAlternative medicineVisual artsPathologyArtInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisCatalytic Cross-Coupling Reactions