Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
Lei Li, Shuaifeng Yang, Xiaoyang Lu, Yongfa Zhang, Tao Li
Abstract
Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.
Topics & Concepts
AutophagyMitochondrionCell biologyEndoplasmic reticulumMechanism (biology)Oxidative stressApoptosisStroke (engine)IntracellularHomeostasisBiologyNeuroscienceMedicineBioinformaticsBiochemistryMechanical engineeringEpistemologyPhilosophyEngineeringMitochondrial Function and PathologyAutophagy in Disease and TherapyAlzheimer's disease research and treatments