The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates
Jiaxin Yang, Yan Li, Shijin Wang, Huili Li, Lili Zhang, Haichen Zhang, Pei‐Hui Wang, Xiangyu Zheng, Xiao‐Fang Yu, Wei Wei
Abstract
Neurologic manifestations associated with many COVID-19 patients, including acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and long COVID, have been proven by increasing evidence. 1 To date, most studies have focused on how SARS-CoV-2 invades the nervous system and the consequent neuropathological changes. 2 , 3 In contrast, the specific mechanism by which SARS-CoV-2 infection leads to neurological disease remains unclear.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ProteaseCleavage (geology)2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Sars virusVirologyChemistryBiologyMedicineEnzymeBiochemistryPathologyInfectious disease (medical specialty)OutbreakDiseaseFracture (geology)PaleontologyLong-Term Effects of COVID-19Tryptophan and brain disordersIntensive Care Unit Cognitive Disorders