Recent developments of oleaginous yeasts toward sustainable biomanufacturing
Paul Adamczyk, Tian Jiang, Karuna Jetty, Vijaydev Ganesan, Di Liu
Abstract
Oleaginous yeast are remarkably versatile organisms, distinguished by their natural capacities to accumulate high levels of neutral lipids and broad substrate range. With recent growing interests in engineering non-model organisms as superior biomanufacturing platforms, oleaginous yeasts have emerged as promising chassis for oleochemicals, terpenoids, organic acids, and other valuable products. Advancement in systems biology along with genetic tool development have significantly expanded our understanding of the metabolism in these species and enabled engineering efforts to produce biofuels and bioproducts from diverse feedstocks. This review examines the latest technical advances in oleaginous yeast research toward sustainable biomanufacturing. We cover recent developments in systems biology-enabled metabolism understanding, genetic tools, feedstock utilization, and strain engineering approaches for the production of various valuable chemicals. • Recent advances have increased our understanding of metabolism in oleaginous yeasts. • Oleaginous yeasts are robust hosts for utilizing various feedstocks. • Diverse biofuels and bioproducts have been made in oleaginous yeasts at high titers.