Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
Elizabeth A. King, Yoo Jin Cho, Nathan S. Hsu, Dustin Dovala, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Topics & Concepts
Transcription factorUbiquitinProteolysisProteasomeComputational biologyBiologySmall moleculeCovalent bondChemistryCell biologyBiochemistryEnzymeGeneOrganic chemistryProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways