circRNA_010383 Acts as a Sponge for miR-135a and its Downregulated Expression Contributes to Renal Fibrosis in Diabetic Nephropathy
Fenfen Peng, Wangqiu Gong, Shu‐Ting Li, Bohui Yin, Chen Zhao, Wenting Liu, Xiaowen Chen, Congwei Luo, Qianying Huang, Ting Chen, Lingzhi Sun, Shun Fang, Weidong Zhou, Zhijian Li, Haibo Long
Abstract
More importantly, the kidney-target of circRNA_010383 overexpression inhibited proteinuria and renal fibrosis in db/db mice. Mechanistically, we identified that a loss of circRNA_010383 promoted proteinuria and renal fibrosis in DN by acting as a sponge for miRNA-135a. This study reveals that circRNA_010383 may be a novel therapeutic target for DN in the future.
Topics & Concepts
Gene knockdownDiabetic nephropathyDownregulation and upregulationFibrosisCancer researchKidneymicroRNADiabetes mellitusCell biologyMedicineInternal medicineEndocrinologyChemistryBiologyApoptosisGeneBiochemistryCircular RNAs in diseasesMicroRNA in disease regulationCardiovascular, Neuropeptides, and Oxidative Stress Research