Greater genetic diversity is needed in human pluripotent stem cell models
Sulagna Ghosh, Ralda Nehme, Lindy E. Barrett
Abstract
While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.
Topics & Concepts
Induced pluripotent stem cellComputational biologyBiologyStem cellDiversity (politics)Genetic diversityEvolutionary biologyEmbryonic stem cellGeneticsGeneMedicinePopulationPolitical scienceLawEnvironmental healthPluripotent Stem Cells ResearchCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics