VX-11e protects articular cartilage and subchondral bone in osteoarthritis by inhibiting the RIP1/RIP3/MLKL and MAPK signaling pathways
Weikang Zhang, Xiaohang Zheng, Yuhang Gong, Ting Jiang, Jianxin Qiu, Xinhui Wu, Fangying Lu, Zhangfu Wang, Zhenghua Hong
Topics & Concepts
ChemistryOsteoclastCartilageWestern blotOsteoarthritisRANKLNecroptosisViability assayMAPK/ERK pathwayAggrecanaseCell biologyMolecular biologyIn vitroPhosphorylationPathologyProgrammed cell deathBiochemistryArticular cartilageAnatomyMedicineApoptosisBiologyActivator (genetics)Alternative medicineGeneinterferon and immune responsesOsteoarthritis Treatment and MechanismsBone Metabolism and Diseases